The group, led by Neil Laughton, will make the 6,000km (3,600-mile) journey by land and air in the Parajet Skycar, effectively a dune buggy with a fan motor and paragliding wing attached.
After taking off from London, the expedition will travel through France, Spain, Morocco, Western Sahara and Mali, and aims to reach Timbuktu on February 20.
The plan is to drive the Skycar where there are roads, and fly over the Straits of Gibraltar, the Atlas mountains in Morocco and the trackless wastes of the Empty Quarter of the Sahara.
Oh, and it runs on bio-fuel. Read more here.